【报告题目】Study of Neurogenesis and Neurotransmitter Alterations in Psychiatric Disorders by Proton Magnetic Resonance Spectroscopy (¹H-MRS)

【报告人】李瑶博士

【邀请人】张志君博士

【时间】3月2日（周四）10:00-11:00

【地点】Med-X 108 （闵行文选楼323会议室同步视频）

【摘要】Magnetic resonance spectroscopy (MRS) provides in vivo metabolic and biochemical information about tissues non-invasively, which has been applied clinically for over two decades. In this talk, I will introduce our work on neurogenesis and neurotransmitter study using proton magnetic resonance spectroscopy (¹H-MRS) with applications in psychiatric disorder. The following aspects will be addressed: (1) Hippocampal neurogenesis in depression patients and the impact of antidepressants/electroconvulsive treatment in patients hippocampal plasticity. (2) The glutamatergic signal dysfunction within cortico-striato-thalamo-cortical (CSTC) circuit of obsessive -compulsive disorder (OCD) patients. (3) Combining MRS with functional magnetic resonance imaging (fMRI) technology, we carried out study of brain metabolism along with brain functional connectivity in OCD. The pathophysiology of OCD includes multiple biological systems that influence each other and the functional alterations are accompanied by neurochemical changes. The multi-modal functional magnetic resonance imaging technology enabled a more comprehensive understanding about the mechanism of psychiatric diseases.

【报告人简介】Dr Yao Li received her B.S. degree from Shanghai Jiao Tong University in 2002, and her Ph.D. degree from the State University of New York at Stony Brook in 2008. She then joined Stony Brook medical center as a postdoctoral associate. She joined the Med-X institute as an associate professor in 2010. Dr. Li was supported by many research agencies including the National Science Foundation in China, Ministry of Science and Technology, Ministry of Education of China, and Shanghai Municipal Science and Technology Committee, etc. She serves as the associate editor in BMC Neuroscience and guest editor in Stem cells international. She is a member of Institute of Electrical and Electronics Engineers (IEEE) and Organization of Human Brain Mapping (OHBM). Her research interests include biomarker quantification with magnetic resonance spectroscopy, multimodal functional magnetic resonance imaging study in mental disorders (e.g., OCD, depression, etc), and laser speckle blood flow imaging.